Detection of mis-specified relationships in inbred and outbred pedigrees

Genome screen data collected for linkage analysis can be used to detect pedigree errors. We have developed methods applicable to a broad range of relationships. We discuss applications of our methods to data on asthma, in which we detect a number of likely mis-specified relative pairs. We propose a graphical method for error detection in complex inbred pedigrees, with application to the Hutterites.