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Detecting genotype x age interaction
L Almasy1, B Towne, C Peterson
1Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, P.O. Box 760549, San Antonio, TX 78245-0549, USA.
Abstract:
This paper explores several extensions to the variance component method, which incorporate genotype x age interaction effects. We evaluate the performance of these methods for detecting genotype x age interaction in quantitative genetic analyses of a quantitative trait (Q4), contrasting this with false positive detection rates obtained from a phenotype influenced by the same genes but without genotype x age interaction effects (Q3). We then assess the impact on linkage power and false positive rate of allowing a QTL-specific genotype x age interaction in linkage analysis of these same traits.