Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene x environment interaction from case-control and case-case approaches.

Y Bai1, L R Goldin, A M Goldstein

  • 1Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Bethesda, MD 20892, USA.

Genetic Epidemiology
|January 17, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia.

Genetics in medicine : official journal of the American College of Medical Genetics·2021
Same author

Risk factors for melanoma by anatomical site: an evaluation of aetiological heterogeneity.

The British journal of dermatology·2020
Same author

Guidelines for the management of postoperative soiling in children with Hirschsprung disease.

Pediatric surgery international·2019
Same author

Associations of pigmentary and naevus phenotype with melanoma risk in two populations with comparable ancestry but contrasting levels of ambient sun exposure.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

International cancer seminars: a focus on esophageal squamous cell carcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Xenotransplantation of human intestine into mouse abdomen or subcutaneous tissue: Novel platforms for the study of the human enteric nervous system.

Neurogastroenterology and motility·2017

This study used genetic analysis data to investigate gene-sex interactions in disease liability. The case-case approach revealed a significant multiplicative interaction effect, highlighting the importance of explicitly defining gene-environment interactions.

Area of Science:

  • Genetics
  • Biostatistics
  • Epidemiology

Background:

  • Understanding genetic contributions to disease liability is crucial.
  • Investigating gene-environment interactions, such as gene-sex effects, can reveal complex disease mechanisms.

Purpose of the Study:

  • To analyze the effects of a major gene and its interaction with sex on disease liability using Genetic Analysis Workshop 12 data.
  • To evaluate the performance of case-control and case-case approaches in detecting gene-environment interactions.

Main Methods:

  • Applied case-control and case-case analytical approaches.
  • Utilized data from the Genetic Analysis Workshop 12.
  • Focused on detecting gene-sex interaction effects on disease liability.

Related Experiment Videos

Main Results:

  • No joint additive effect of the major gene and sex was detected.
  • The case-case approach identified a statistically significant multiplicative interaction effect between the gene and sex.
  • This interaction effect could not be attributed to random error.

Conclusions:

  • The case-case approach is effective in detecting multiplicative gene-environment interactions, even when not explicitly simulated as additive.
  • Explicitly defining and measuring gene-environment interactions is critical for accurate analysis of real-world genetic data.
  • This study underscores the importance of considering interaction effects in genetic association studies.