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Related Experiment Videos

[Propionic acidemia and sodium dipropylacetate].

B Cherruau, M Mangeot, J F Demelier

    Comptes Rendus Des Seances De L'Academie Des Sciences. Serie D, Sciences Naturelles
    |September 24, 1979
    PubMed
    Summary
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    Sodium dipropylacetate caused hyperglycinemia and hyperglycinuria in rats but did not affect propionic acid levels or hepatic propionyl-CoA carboxylase activity.

    Area of Science:

    • Biochemistry
    • Metabolic disorders
    • Animal studies

    Context:

    • Investigating the metabolic effects of sodium dipropylacetate.
    • Examining the role of biotin deficiency in metabolic pathways.

    Purpose:

    • To determine the impact of sodium dipropylacetate on amino acid and organic acid metabolism.
    • To assess the effect of sodium dipropylacetate on hepatic propionyl-CoA carboxylase activity.

    Summary:

    • Administration of sodium dipropylacetate to rats led to hyperglycinemia and hyperglycinuria.
    • No significant accumulation of propionic acid in blood or urine was observed.
    • Hepatic propionyl-CoA carboxylase activity remained unchanged, and sodium dipropylacetate did not inhibit this enzyme.

    Impact:

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    • Provides insights into the metabolic fate of sodium dipropylacetate.
    • Clarifies that sodium dipropylacetate does not induce propionic acidemia through propionyl-CoA carboxylase inhibition.