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Published on: November 23, 2017
A mediator of cell surface-specific plasmin generation
C Brownstein1, D J Falcone, A Jacovina
1Department of Pediatrics, Weill Medical College of Cornell University, New York, New York 10021, USA.
Annals of the New York Academy of Sciences
|January 25, 2002
Summary
Annexin II acts as a cell surface receptor, facilitating plasmin generation crucial for blood vessel formation and vascular health. Its role extends to monocyte migration and has implications in leukemia and atherosclerosis.
Area of Science:
- Cell Biology
- Biochemistry
- Physiology
Background:
- Cell surface proteases, like plasmin, are vital for numerous in vivo biological processes.
- Cell surface receptors regulate proteolysis, offering protection from inhibitors and enhancing catalytic efficiency.
Purpose of the Study:
- To describe annexin II as a cell surface receptor and coreceptor for tissue plasminogen activator and plasminogen.
- To elucidate the multifaceted roles of annexin II in various physiological and pathological conditions.
Main Methods:
- The study is primarily descriptive, based on existing evidence and observations.
- Investigates the expression and function of annexin II across different cell types.
Main Results:
- Annexin II is expressed on endothelial cells, tumor cells, monocytes, macrophages, and neuronal cells.
- Annexin II is crucial for efficient cell surface plasmin generation, angiogenesis, and vascular patency.
- Annexin II expression is linked to bleeding diathesis in acute promyelocytic leukemia and may play a role in atherosclerotic plaque formation.
- Annexin II on monocytes/macrophages contributes to extracellular matrix degradation and cell migration.
Conclusions:
- Annexin II is a key cell surface receptor with significant roles in vascular biology, immune responses, and disease pathogenesis.
- Further research into annexin II function could yield therapeutic strategies for vascular diseases, leukemia, and inflammatory conditions.
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