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Study on PDGF receptor beta pathway in glomerular formation in neonate mice
1Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Japan.
Annals of the New York Academy of Sciences
|January 25, 2002
Abstract:
The assembly of vascular endothelial cells (ECs) and smooth muscle cells is a critical event in the development of the cardiovascular system. Although the role of ECs in this event has been studied intensively, the cross-talk between the two cell components remains poorly understood. In this study, we blocked platelet-derived growth factor receptor (PDGFR) pathways in mice by antagonistic rat monoclonal antibody APB5 against murine PDGFR-beta and examined glomerular capillary formation.
