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Caloric restriction in primates.

M A Lane1, A Black, A Handy

  • 1Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. MLANE@vms.grc.nia.nih.gov

Annals of the New York Academy of Sciences
|January 25, 2002
PubMed
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Caloric restriction (CR) in primates shows physiological benefits similar to rodents, potentially delaying age-related diseases. While lifespan extension isn

Area of Science:

  • Gerontology
  • Nutritional Science
  • Comparative Biology

Background:

  • Caloric restriction (CR) is a proven intervention extending lifespan and healthspan in short-lived mammals.
  • CR's effects on aging and age-related diseases in longer-lived species, particularly primates, were previously unknown.

Purpose of the Study:

  • To investigate the physiological effects of CR in nonhuman primates.
  • To assess the potential of CR to delay or prevent age-related diseases in primates.

Main Methods:

  • Long-term studies involving nonhuman primates undergoing CR at the National Institute on Aging (NIA) and University of Wisconsin-Madison (UW).
  • Monitoring of physiological responses and age-related disease markers in CR primates compared to control groups.

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Main Results:

  • Primates on CR exhibited physiological responses nearly identical to those observed in laboratory rodents.
  • Preliminary data suggest CR may prevent or delay cardiovascular disease, diabetes, and cancer in primates.
  • CR may reduce mortality associated with age-related diseases in primates.

Conclusions:

  • CR in primates elicits beneficial physiological responses similar to those in rodents.
  • Emerging data suggest CR may offer protection against age-related diseases in primates.
  • While conclusive lifespan extension data in primates is pending, findings support CR's potential benefits for primate and human aging.