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An aldol-based approach to the synthesis of the antibiotic anisomycin
Alison N Hulme1, Edward M Rosser
1Department of Chemistry, The University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK.
Organic Letters
|February 14, 2002
Abstract:
[reaction: see text] A new approach to the synthesis of the antibiotic anisomycin is reported that relies upon a key aldol disconnection. The glycolate aldol coupling proceeds in 75% yield and with >95% diastereoselectivity, which allows the 13-step synthesis to proceed in 35% overall yield.