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BRENDA: a resource for enzyme data and metabolic information
Ida Schomburg1, Antje Chang, Oliver Hofmann
1University of Cologne, Institute of Biochemistry, Zülpicher Strasse 47, 50674, Köln, Germany.
Trends in Biochemical Sciences
|February 14, 2002
Summary
BRENDA (BRaunschweig ENzyme DAtabase) is a comprehensive database detailing enzyme functions and metabolic pathways. It serves as a vital resource for scientific research across various fields, including biotechnology and pharmacology.
Area of Science:
- Biochemistry
- Bioinformatics
- Enzymology
Background:
- BRENDA (BRaunschweig ENzyme DAtabase) is a curated database established in 1987.
- It compiles enzymatic and metabolic information from scientific literature.
- The database covers over 40,000 enzymes and 4,460 organisms.
Purpose of the Study:
- To provide a comprehensive resource for protein function and enzyme data.
- To facilitate research in areas such as biotechnology, pharmacology, and metabolism.
- To detail enzyme-ligand relationships and chemical compound interactions.
Main Methods:
- Data extraction from primary scientific literature.
- Curation and organization of enzymatic and metabolic information.
- Inclusion of enzyme-ligand and chemical compound relationship data.
Main Results:
- A substantial collection of data on enzymes and organisms.
- Detailed information on enzyme functions and metabolic pathways.
- Cross-referenced data on enzyme-ligand interactions.
Conclusions:
- BRENDA is a fundamental resource for diverse scientific disciplines.
- The database supports research in enzyme mechanics, medicinal diagnostics, and drug discovery.
- Accessible data promotes advancements in biotechnology and metabolic studies.