Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calmodulin is a limiting factor in the cell.

Anthony Persechini1, Paul M Stemmer

  • 1School of Biological Sciences, Division of Molecular Biology & Biochemistry, University of Missouri-Kansas City, Kansas City, MO 64110-2499, USA. persechinia@umkc.edu

Trends in Cardiovascular Medicine
|February 14, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-specific in utero reprogramming of lung immunity.

Mucosal immunology·2026
Same author

Metastasis suppressing properties of the cell-surface anchored serine protease prostasin: new functional and mechanistic insights from breast cancer.

Oncogenesis·2026
Same author

Integrative Proteomic and Bioenergetic Profiling Reveals Diet- and Strain-Specific Mitochondrial Dysfunction in Cohen Diabetic Rat Hearts.

Antioxidants (Basel, Switzerland)·2026
Same author

O-GlcNAc modification differentially regulates microtubule binding and pathological conformations of tau isoforms in vitro.

The Journal of biological chemistry·2025
Same author

Interactions of VMAT2 with CDCrel-1 and Parkin in Methamphetamine Neurotoxicity.

International journal of molecular sciences·2024
Same author

New Processes for Ionizing Nonvolatile Compounds in Mass Spectrometry: The Road of Discovery to Current State-of-the-Art.

Journal of the American Society for Mass Spectrometry·2024
Same journal

Artificial Intelligence in Echocardiography for Valvular Heart Disease.

Trends in cardiovascular medicine·2026
Same journal

Inflammation as a Fulcrum in Cardiovascular Disease: The Evolving Case for High-Sensitivity C-Reactive Protein.

Trends in cardiovascular medicine·2026
Same journal

Comment on "advancing personalised care in atrial fibrillation and stroke: The potential impact of AI from prevention to rehabilitation".

Trends in cardiovascular medicine·2026
Same journal

Response to: Comment on "Advancing personalised care in atrial fibrillation and stroke: The potential impact of AI from prevention to rehabilitation" (TCM-D-26-00198).

Trends in cardiovascular medicine·2026
Same journal

High-sensitivity C-reactive protein as a prognostic biomarker in cardiovascular diseases: implications for atherosclerosis, chronic kidney disease, and heart failure - a review.

Trends in cardiovascular medicine·2026
Same journal

The cost of false dichotomies in a dynamic disease.

Trends in cardiovascular medicine·2026
See all related articles

Calmodulin (CaM) is limited in cells, impacting its regulation of targets. This scarcity allows CaM-dependent pathways to interact, influencing cellular signaling.

Area of Science:

  • Cellular biology
  • Molecular signaling
  • Biochemistry

Background:

  • Calmodulin (CaM) is a crucial calcium-binding protein involved in numerous cellular processes.
  • The intracellular concentration of CaM is often lower than that of its diverse protein targets.
  • This concentration difference suggests CaM may act as a limiting factor in signal transduction.

Purpose of the Study:

  • To review the implications of a limited intracellular calmodulin concentration on cellular signaling pathways.
  • To explore how competition for calmodulin influences the cross-talk between different signaling cascades.

Main Methods:

  • Literature review of studies on calmodulin concentration, function, and signaling.
  • Analysis of theoretical models and experimental data regarding CaM-target interactions.

Related Experiment Videos

  • Synthesis of current understanding of CaM-mediated regulation.

    • Main Results:

    • Intracellular CaM concentration is significantly below the total concentration of its targets.
    • This limitation positions CaM as a critical regulatory factor rather than a passive component.
    • Competition for the limited CaM pool is a key mechanism for pathway integration.

    Conclusions:

    • A limited CaM pool enables intricate cross-talk between CaM-dependent signaling pathways.
    • This competition provides a mechanism for integrating diverse cellular signals.
    • Understanding CaM limitation is essential for deciphering complex cellular regulation.