Related Experiment Videos
HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c
Michèl R Klein1, Abdulrahman S Hammond, Steve M Smith
1TB Research Programme, MRC Laboratories, Fajara, The Gambia. petiet@stanford.edu
Infection and Immunity
|January 18, 2002
Abstract:
Few human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach. Peptide-specific CD8 T cells were able to kill M. tuberculosis-infected macrophages and produce gamma interferon and tumor necrosis factor alpha.