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Leishmania major promastigotes inhibit dendritic cell motility in vitro
Heather Jebbari1, Andrew J Stagg, Robert N Davidson
1Antigen Presentation Research Group, Department of Immunology, Imperial College School of Medicine, Northwick Park Hospital, Harrow, London HA1 3UJ, United Kingdom. hjebbari@yahoo.co.uk
Infection and Immunity
|January 18, 2002
Abstract:
Using an in vitro transwell migration assay, we have demonstrated that products secreted by Leishmania major promastigotes inhibit the motility of dendritic cells (DC) by up to 93%. Inhibition was dose dependent and reversible. By inhibiting DC migration in vivo, L. major may therefore subvert DC from their potentially protective role during leishmaniasis.