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Updated: Jul 27, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Enoxaparin-associated severe retroperitoneal bleeding and abdominal compartment syndrome: a report of two cases
1Division of Nephrology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St. Louis, MO 63110, USA.
Objective:
To describe a complication of low-molecular-weight heparin (enoxaparin) in the setting of critically ill patients.
Design:
Case report.
Setting:
The medical and surgical intensive care units of a tertiary care university teaching hospital.
Patients:
Two adult patients receiving enoxaparin developed retroperitoneal hematoma and abdominal compartment syndrome. Both patients became anuric and required high-dose intravenous fluids and vasopressors to maintain blood pressure.
Intervention:
Discontinuation of enoxaparin, followed by exploratory laparotomy and evacuation of the hematoma.
Measurements And Results:
Immediate clinical improvement following evacuation of hematoma.
Conclusions:
High-risk patients receiving low-molecular-weight heparin should be identified and closely monitored to prevent serious bleeding complications.
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