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Alcohol and false recognition: a dose-effect study.

M Z Mintzer1, R R Griffiths

  • 1Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA. mmintzer@jhmi.edu

Psychopharmacology
|January 18, 2002
PubMed
Summary
This summary is machine-generated.

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Alcohol consumption did not significantly alter false recognition rates in healthy volunteers. This study investigated alcohol

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Pharmacology

Background:

  • Alcohol-induced memory impairment resembles benzodiazepine effects.
  • Previous research suggests benzodiazepines decrease false recognition, but alcohol's effect is debated.
  • False recognition involves mistakenly identifying novel items as previously encountered.

Purpose of the Study:

  • To investigate the acute dose-dependent effects of alcohol on false recognition.
  • To compare alcohol's impact on false recognition with known benzodiazepine effects.

Main Methods:

  • A placebo-controlled, double-blind, repeated-measures design was used.
  • Eighteen healthy volunteers received alcohol doses of 0.27 g/kg and 0.60 g/kg.
  • Performance was assessed using the Deese/Roediger-McDermott false recognition paradigm.

Related Experiment Videos

Main Results:

  • A high alcohol dose (0.60 g/kg) reduced true recognition (hit rate) and increased response bias (C).
  • Neither alcohol dose significantly affected discrimination sensitivity (d') between old and new words.
  • Crucially, neither alcohol dose altered false recognition rates.

Conclusions:

  • Alcohol's effects on false recognition and response bias may differ from benzodiazepines.
  • Further research directly comparing equivalent doses of alcohol and benzodiazepines is needed.
  • Qualitative differences in cognitive effects between these substances remain to be elucidated.