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[Alkaline phosphatase].
1Department of Clinical Laboratory, Nagoya Ekisaikai Hospital.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|January 19, 2002
Summary
Elevated alkaline phosphatase can indicate bone or liver disease. Gamma-glutamyl transpeptidase and alkaline phosphatase isozyme patterns help pinpoint the origin of high alkaline phosphatase levels for accurate diagnosis.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Medical Diagnostics
Context:
- Elevated alkaline phosphatase (ALP) activity is a common clinical finding.
- High ALP levels are associated with bone diseases (e.g., increased osteoblastic activity) and hepatobiliary conditions (e.g., biliary obstruction).
- Transient hyperphosphatasemia can occur in children.
Purpose:
- To differentiate the origin of elevated alkaline phosphatase (ALP) activity.
- To distinguish between bone and liver-derived ALP.
- To aid in the diagnosis of various pathological states.
Summary:
- High alkaline phosphatase (ALP) activity can stem from bone disease or hepatobiliary issues.
- Gamma-glutamyl transpeptidase (GGT) levels are used to differentiate the source of elevated ALP; normal GGT suggests bone origin.
- Serum ALP isozyme patterns via electrophoresis are essential for definitive pathological state differentiation.
Impact:
- Provides crucial diagnostic information for differentiating bone and liver diseases.
- Enhances diagnostic accuracy in clinical chemistry.
- Supports targeted treatment strategies based on the identified source of elevated ALP.