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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...

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Updated: Jul 16, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

Approaching cancer pain relief.

J N Lickiss1

  • 1Sydney Institute of Palliative Medicine, Camperdown, New South Wales, Australia.

European Journal of Pain (London, England)
|January 19, 2002
PubMed
Summary

Effective pain management requires understanding the patient as a whole person and employing a systematic approach. This includes open communication, thorough assessment, and tailored pharmacological and non-pharmacological interventions for optimal relief.

Area of Science:

  • Palliative Care
  • Pain Management
  • Oncology

Background:

  • Pain is a subjective experience requiring a holistic understanding of the patient.
  • Effective pain relief necessitates a structured approach, considering the individual's personal, environmental, and cultural context.
  • Palliative care models emphasize comprehensive patient assessment and tailored treatment plans.

Purpose of the Study:

  • To outline a systematic approach to pain relief in cancer patients.
  • To highlight the importance of patient-centered communication in understanding pain experiences.
  • To detail appropriate pharmacological and non-pharmacological interventions for diverse pain types.

Main Methods:

  • Gathering comprehensive patient history, including their perception of the cancer journey and pain.

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  • Conducting thorough clinical examinations to identify pain mechanisms.
  • Utilizing a stepwise pharmacological approach, including analgesics, opioids, and adjuvant medications.
  • Addressing psychosocial factors and providing patient education on medication use and side effects.
  • Main Results:

    • A structured approach integrating patient narrative, clinical assessment, and targeted interventions can achieve pain relief.
    • Effective management involves understanding pain's evolution, exacerbating/alleviating factors, and underlying mechanisms.
    • Appropriate use of analgesics, opioids (e.g., morphine), and adjuvant therapies (antidepressants, anticonvulsants) is crucial for diverse pain types, including neuropathic pain.
    • Addressing bowel function and patient concerns (e.g., addiction, tolerance) is essential for safe and effective opioid therapy.

    Conclusions:

    • A comprehensive, patient-centered approach is fundamental for successful pain management in oncology.
    • Systematic assessment and tailored treatment strategies, including appropriate medication selection and administration, are key to achieving pain relief.
    • Ongoing evaluation and adjustment of the pain management plan are necessary to ensure optimal patient outcomes.