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Use of morphine and adjuvant drugs according to the condition
1Kitasato University School of Medicine, Department of Anesthesiology, Kitasato Sagamihara City, Kanagawa, Japan. nopain@med.kitasato-u.ac.jp
European Journal of Pain (London, England)
|January 19, 2002
Abstract:
Adjuvant drugs are used to enhance effects of analgesics and morphine-resistant pain such as neuropathic pain. If morphine provides inadequate pain relief and evokes drowsiness, morphine is usually ineffective. The key is the patient's reaction to morphine. When a patient's pain includes neuropathic pain, a combination of morphine and non-steroidal anti-inflammatory drugs is partially effective, but morphine-resistant pain remains. Increasing morphine dosage causes drowsiness without pain improvement. Appropriate adjuvant drugs are necessary in these conditions.