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[Study on the relation between hypertensive left ventricular hypertrophy in very old people with neurohormonal

H Guo1, D Lu, J Wang

  • 1The Affiliated Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou 310016, China.

Zhonghua Nei Ke Za Zhi
|January 19, 2002
PubMed

Insights

In very old adults, hypertensive left ventricular hypertrophy (LVH) is linked to higher aldosterone and insulin levels, increasing the risk of ventricular arrhythmias and ischemia.

Area of Science:

  • Cardiology
  • Geriatrics
  • Endocrinology

Context:

  • Hypertensive left ventricular hypertrophy (LVH) is a common complication in the elderly.
  • The relationship between neuro-hormonal factors and ventricular arrhythmias in very old individuals with LVH requires further investigation.

Purpose:

  • To investigate the association between hypertensive LVH and neuro-hormone levels in individuals over 80 years old.
  • To determine the correlation between these factors and the incidence of ventricular arrhythmias.

Summary:

  • This study compared 30 elderly patients with hypertension and LVH to 30 with simple hypertension.
  • Measurements included heart rate variability, renin, angiotensin-II, aldosterone, insulin, and Holter monitoring.
  • Results showed significantly higher aldosterone and insulin levels, increased sympathetic nerve activity (VLF, LF, LF/HF), and a greater incidence of premature ventricular beats and myocardial ischemia in the LVH group.

Impact:

  • Hypertensive LVH in the elderly is closely associated with aldosterone and insulin levels, not renin or angiotensin-II.
  • Increased sympathetic nerve excitability and higher aldosterone/insulin levels contribute to ventricular arrhythmias and ischemia in this population.
Abstract

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