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[Retrospective cohort study on the prognosis of chronic myeloid leukemia]
1Department of Hematology, Huashan Hospital, Shanghai Medical University, Shanghai 200040, China.
Objective:
To evaluate the prognostic factors of chronic myeloid leukemia (CML).
Methods:
Survival curves were plotted according to the Kaplan-Meier method. Variables associated with prognosis were analyzed by Logrank test. A multivariate analysis of prognostic factors was performed using stepwise Cox model.
Results:
Of the total 158 patients, the median survival time was 1,480 days. 5 years survival rate was 47.1% (95% CI, 36.7% - 56.9%). 10 years was 24.8% (95% CI, 15.0% - 35.8%). The predominant blastic crisis type is myeloblastic, myelomonocytic or monocytic(77.5%). The period from chronic phase to blastic phase was equal in myelosuppressive therapy group, non- myelosuppressive therapy group or altretamine (HMM) group. After evaluated by stepwise Cox's regression model, age>or=50 years, bone marrow blasts>or=0.05, bone marrow basophilic>or=0.05, Ph chromosome negative and HMM treatment were associated with poor prognosis. Hydroxyurea was always associated with longer survival.
Conclusion:
Age, Ph chromosome, bone marrow blasts and basophilic, and various treatment affected the survival of CML.