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[BRCA1 gene mutations in early-onset breast cancer]
Zhonghua Yi Xue Za Zhi
|January 19, 2002
Abstract
Objective:
To detect BRCA1 gene mutations in early-onset breast cancer.
Methods:
We use polymerase chain reaction and single strand conformation polymorphism analysis (PCR-SSCP) to examine the mutation at BRCA1 gene exon 2, 11 and 20 in 10 patients with early-onset breast cancer.
Results:
Mutation was found in one cases (24 years old at diagnosis) at nucleotide 3 732, the substitution of a "G" to a "C" in codon 1 205 changed a Gly to a Arg.
Conclusions:
Our data suggest that BRCA1 may have effect on early-onset breast cancer.