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[Carcinogenicity of bile from cholecystolithiasis patients]
1Department of General Surgery, First Hospital, Dalian Medical University, Dalian 116011, China.
Objective:
To study the carcinogenicity of bile from cholecystolithiasis patients and the relationship between cholecystolithiasis and gallbladder carcinoma (GBC).
Methods:
The bile from 18 cholecystolithiosis patients was examined by Ames test and two-stage cell transformation assay.
Results:
The bile from cholecystolithiosis patients could significantly promote the formation of BALB/c3T3 cell transformation (P = 0.0233). The bile from symptomatic patients was much more active in tumor promotion than that from asymptomatic patients (P < 0.05).
Conclusion:
The bile in cholecystolithiasis patients exhibits a tumor-promoter activity, which may account for the high incidence of GBC among cholecystolithiasis patients.