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[Association between estrogen receptor gene polymorphisms and acute myocardial infraction]
1Department of Laboratory Science, Renmin Hospital, Wuhan University, Wuhan 430060, China.
Objective:
To study the distribution of estrogen receptor (ER) in Chinese Hans population and the association of ER gene polymorphisms with acute myocardial infarction (AMI).
Methods:
ER genotyping was performed in 75 AMI patients and 118 controls by PCR-RFLP. The serum lipid levels of the subjects were also determined. 46 AMI patients were examined by selected coronary angiography (SCA).
Results:
ER allelic frequencies of X, x and P, p alleles were 0.207, 0.793; 0.169, 0.831 and 0.287, 0.713; 0.399, 0.661 in AMI and control groups respectively. There was no significant difference between the distribution of Xbal and PvaII polymorphisms in AMI group and control group (P > 0.05). The serum lipid levels and the results of SCA were also not significantly difference among genotypes in intra-group. But the distributions of PvuII genotypes were significantly different between AMI group and controls (P < 0.05).
Conclusion:
XbaI polymorphisms are not related to AMI. But PvuII polymorphisms are associated with AMI, they might be a risk factor for AMI.