Immunopathogenesis of vasculitis

Vasculitis is defined by the presence of leukocytes in the vessel wall with reactive damage to mural structures, leading to tissue ischemia and necrosis. The immunopathologic events that initiate the process of vascular inflammation and blood vessel damage are unclear. Damage of vascular endothelial cells and the recruitment and accumulation of the inflammatory infiltrate are determined by the endothelial cell and the bystanders, including the expression of adhesion molecules, the secretion of peptides and hormones, and the specific interaction with inflammatory cells. In addition to the endothelial cells, which provide costimulatory function, other cellular components and nonendothelial structures of the vessel wall are involved in controlling the inflammatory process, serve as antigen-presenting cells, and contribute with inflammatory mediators.