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Related Experiment Videos

Sodium ion specifically modifies plasma ionized calcium concentration.

T Akimoto1, Y Ando, H Takahashi

  • 1Department of Nephrology, Jichi Medical School, Tochigi, Japan.

American Journal of Nephrology
|January 19, 2002
PubMed
Summary

Sodium (Na) specifically influences plasma ionized calcium (iCa) levels, independent of pH. This suggests Na modulates calcium binding to plasma proteins, impacting iCa concentration.

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Area of Science:

  • Biochemistry
  • Physiology
  • Clinical Chemistry

Background:

  • A recent observation noted a decline in plasma ionized calcium (iCa) after consuming a sodium-free beverage.
  • Both plasma pH and sodium (Na) correlated with iCa, with Na showing a stronger correlation.

Purpose of the Study:

  • To investigate the specific effect of sodium (Na) on plasma ionized calcium (iCa) concentrations.
  • To determine if Na influences iCa independently of plasma pH.

Main Methods:

  • Human plasma was diluted with various solutions (saline, glucose, KCl, water) to assess dilution effects on iCa.
  • Isovolumetric increases in ion concentration and osmolarity were induced by adding NaCl, KCl, or D-glucose to plasma.
  • Electrolytes, pH, and osmolarity were measured using ion-selective electrodes.

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Main Results:

  • Plasma dilution decreased iCa, but normal saline resulted in a significantly smaller decrease compared to other solutions.
  • Increasing plasma osmolarity with NaCl led to a significant iCa increase (r = 0.604, p < 0.01).
  • No significant change in iCa was observed with KCl or D-glucose addition; NaCl decreased iCa in protein-free solutions.

Conclusions:

  • Sodium (Na) specifically impacts plasma ionized calcium (iCa) levels.
  • The effect of Na on iCa appears independent of plasma pH.
  • Na likely influences iCa by modulating calcium binding to plasma proteins.