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Chromosomal effects of adeno-associated virus vector integration
Daniel G Miller1, Elizabeth A Rutledge, David W Russell
1Department of Medicine, University of Washington, Seattle, Washington, 98195, USA.
Nature Genetics
|January 19, 2002
Abstract:
Adeno-associated virus (AAV) vectors are currently being used in several clinical gene-therapy trials (see the NIH OBA Human Gene Transfer Clinical Trials Database); however, little is known about the chromosomal effects of vector integration. Here we report that integrated vector proviruses are associated with chromosomal deletions and other rearrangements and are frequently located on chromosome 19 (although not at the wildtype AAV integration site).