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Updated: Aug 14, 2026

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells
Published on: June 5, 2015
Monoclonal antibodies in the immunotherapy of autoimmune diseases
F Perosa1, G Luccarelli, M Prete
1Sezione di Medicina Interna, Dipartimento di Scienze Biomediche e Oncologia Umana, Università degli Studi di Bari. f.perosa@dimo.uniba.it
Abstract:
The present report critically reviews the rationale, clinical effectiveness and limits of monoclonal antibody-based immunotherapy in the treatment of autoimmune diseases, with particular emphasis on tumor necrosis factor-alpha blocking reagents. Reference will also be made to active immunotherapy whereby an endogenous response induced by anti-idiotypic monoclonal antibodies or peptides toward molecules regarded as passive immunotherapy targets, is expected to mediate the therapeutic effects.
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