[The effects of the polysaccharides from Dermatocarpon miniatum on oxygen radicals and lipid peroxidation]

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Published on: August 15, 2025

J Jin1, X Bian, P Ge

  • 1Xi'an Jiao Tong University, Xi'an 710061.

Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials
|January 22, 2002
PubMed
Abstract

Insights

Dermatocarpon miniatum polysaccharides effectively scavenge harmful oxygen radicals and inhibit lipid peroxidation. These antioxidant activities increase with higher concentrations of the polysaccharides.

Area of Science:

  • Biochemistry
  • Natural Product Chemistry
  • Antioxidant Research

Context:

  • Oxidative stress and lipid peroxidation are implicated in various pathologies.
  • Natural compounds are increasingly investigated for their therapeutic potential.
  • Dermatocarpon miniatum is a lichen with potential bioactive compounds.

Purpose:

  • To investigate the antioxidant capacity of Dermatocarpon miniatum (DEM) polysaccharides.
  • To evaluate the inhibitory effect of DEM polysaccharides on lipid peroxidation.
  • To quantify the radical scavenging activity of DEM polysaccharides.

Summary:

  • DEM polysaccharides demonstrated significant scavenging activity against hydroxyl radicals (.OH) with an EC50 of 1.72 mg/ml and superoxide radicals (O2-.) with an EC50 of 2.12 mg/ml.
  • The polysaccharides were found to inhibit lipid peroxidation, as evidenced by a reduction in malondialdehyde (MDA) content.
  • The antioxidant and anti-lipid peroxidation activities of DEM polysaccharides were dose-dependent.

Impact:

  • Highlights the potential of DEM polysaccharides as a source of natural antioxidants.
  • Suggests DEM polysaccharides could be valuable in combating oxidative stress-related conditions.
  • Provides quantitative data on the radical scavenging and lipid peroxidation inhibitory effects of DEM polysaccharides.

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