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Calcium channel blockers intake and psoriasis: a case-control study.

A D Cohen1, M Kagen, M Friger

  • 1Department of Dermatology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. arcohen@bgumail.bgu.ac.il

Acta Dermato-Venereologica
|January 22, 2002
PubMed
Summary

Calcium channel blockers may trigger or worsen psoriasis. This case-control study found a significant association between calcium channel blocker use and psoriasis development or exacerbation.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Cell Biology

Background:

  • Intracellular calcium metabolism impacts keratinocyte differentiation.
  • Limited evidence links calcium channel blockers (CCBs) to psoriasis exacerbation.
  • Psoriasis is a chronic inflammatory skin condition.

Purpose of the Study:

  • To investigate the association between CCB exposure and psoriasis.
  • To determine if CCBs precipitate or exacerbate psoriasis.
  • To identify specific CCBs involved.

Main Methods:

  • A case-control study design was employed.
  • Retrospective analysis of 150 psoriasis patients and 150 matched controls.
  • CCB exposure was recorded and analyzed.

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Main Results:

  • 13% of psoriasis patients used CCBs.
  • CCBs were associated with new-onset (2 cases) and exacerbated (11 cases) psoriasis.
  • Nifedipine, felodipine, and amlodipine were the identified CCBs.

Conclusions:

  • CCB intake is significantly associated with psoriasis.
  • CCBs may act as precipitating or exacerbating factors in psoriasis.
  • Further research into the mechanism is warranted.