Related Experiment Video
Updated: Aug 9, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
A case of exaggerated mosquito-bite hypersensitivity with Epstein-Barr virus-positive inflammatory cells in the bite
T Ohsawa1, T Morimura, Y Hagari
1Department of Dermatology, Faculty of Medicine, Tottori University, Yonago, Japan.
Abstract:
We describe a unique patient with mosquito-bite hypersensitivity who had extremely high titres of Epstein-Barr virus antibodies. For many years he developed intractable ulcers on the sites of mosquito-bite. Epstein-Barr virus infection was detected in almost all inflammatory cells in the ulcers and in the peripheral blood lymphocytes by using in situ hybridization to Epstein-Barr virus-encoded small ribonucleic acids and by polymerase chain reaction to Epstein-Barr virus DNA. The inflammatory cells in the ulcers were positive for T-cell marker. Our results suggest that the Epstein-Barr virus infection in T cells may participate in the pathogenesis of exaggerated mosquito hypersensitivity and in delayed healing of ulcers on the sites of mosquito-bite.
Related Concept Videos
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Rocky Mountain Spotted Fever
Arboviral Encephalitis
Yellow Fever
Encephalitis l: Introduction
Hypersensitivity Reactions: Immune-Complex Reactions

