Bone lesions in pigmented villonodular synovitis

Area of Science:

• Orthopedic Surgery
• Radiology
• Pathology

Background:

• Pigmented villonodular synovitis (PVNS) is a rare, benign neoplastic proliferation of the synovium.
• Bone invasion is an uncommon but significant manifestation of PVNS.
• Understanding PVNS bone involvement is crucial for diagnosis and management.

Purpose of the Study:

• To describe seven cases of PVNS with bone invasion.
• To elucidate the pathogenesis and radiographic features of bone changes in PVNS.
• To discuss treatment strategies for PVNS involving bone.

Main Methods:

• Case series review of seven patients with histopathologically confirmed PVNS and bone invasion.
• Radiographic analysis including X-rays, CT, and MRI of affected joints.
• Review of treatment approaches and outcomes.

Main Results:

• Seven cases reported: four hip, one knee, one shoulder, one ankle.
• Detailed description of radiographic findings indicating bone erosion and infiltration.
• Pathogenesis of bone changes linked to proliferative synovial tissue.

Conclusions:

• PVNS can lead to significant bone destruction, mimicking aggressive lesions.
• Accurate radiographic assessment is vital for identifying bone invasion.
• Multidisciplinary approach is recommended for optimal treatment of PVNS with bone involvement.