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Uveitis in a child: masquerade syndrome revisit
L O Atchaneeyasakul1, P Tarinvorakup, A Trinavarat
1Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Summary
Ocular inflammation may signal a relapse of acute lymphoblastic leukemia (ALL) even without systemic signs. Prompt anterior chamber paracentesis is crucial for early diagnosis and treatment of ALL relapse.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Acute lymphoblastic leukemia (ALL) can present with ocular manifestations.
- Uveitis masquerade syndrome can mimic inflammatory conditions.
Observation:
- A patient with a history of ALL developed anterior uveitis.
- The uveitis initially responded to topical steroids but recurred.
- Anterior chamber paracentesis revealed leukemic cells.
Findings:
- The patient experienced a bone marrow relapse three months after initial ocular symptoms.
- Aqueous fluid cytology confirmed anterior chamber relapse of ALL.
- The patient ultimately succumbed to septicemia despite chemotherapy.
Implications:
- Anterior chamber paracentesis is vital for diagnosing ocular ALL relapse.
- Ocular symptoms may precede systemic relapse in ALL patients.
- Timely diagnosis and intervention are critical for managing ALL ocular relapse.