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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Squamous cell carcinomas arising from adnexal ductal cysts
Henry G Skelton1, Steven Flax, Lawrence Chang
1Department of Dermatology, University of Alabama, Birmingham 35294-0009, USA. hskelton@path.uab.edu
Archives of Pathology & Laboratory Medicine
|January 22, 2002
Summary
Malignant tumors from adnexal cysts are rare. This study identifies human papillomavirus (HPV)-16 in two squamous cell carcinomas arising from adnexal ducts, suggesting a potential link to skin cancer development.
Area of Science:
- Dermatopathology
- Oncology
- Virology
Background:
- Malignant tumors originating from adnexal cysts are infrequently encountered in clinical practice.
- The pathogenesis of some cutaneous squamous cell carcinomas remains unclear, particularly those without a clear epidermal origin.
Observation:
- Two cases of squamous cell carcinoma (SCC) developing within adnexal ductal cysts were analyzed.
- In situ hybridization and immunohistochemical staining were performed to detect human papillomaviruses (HPV) and p53 expression.
Findings:
- Both cases demonstrated focal expression of HPV-16 within areas exhibiting squamoid differentiation.
- Diffuse p53 expression was observed in the invasive portions of the squamous cell carcinomas.
- This is the first report identifying the highly oncogenic HPV-16 subtype in SCCs arising from adnexal ductal structures.
Implications:
- The findings suggest a potential role for HPV-16 in the development of SCCs originating from adnexal ducts.
- This may provide an explanation for primary cutaneous squamous cell carcinomas lacking epidermal origin.
- Further research into HPV's role in adnexal neoplasms is warranted.
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