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Related Experiment Videos

Anomalous dynamics of translocation.

Jeffrey Chuang1, Yacov Kantor, Mehran Kardar

  • 1Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|January 22, 2002
PubMed
Summary

Polymer translocation through pores exhibits anomalous dynamics. Simulations reveal translocation times scale with polymer length (N) similar to diffusion, not Brownian motion predictions, indicating complex behavior.

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Area of Science:

  • Polymer physics
  • Biophysics
  • Computational chemistry

Background:

  • Polymer translocation through nanopores is crucial for biological processes and nanotechnology.
  • Existing models based on Brownian dynamics predict a mean passage time scaling of N^2.
  • Rouse dynamics suggest a scaling exponent greater than two for free polymer diffusion, posing a discrepancy.

Purpose of the Study:

  • Investigate polymer translocation dynamics beyond Brownian motion predictions.
  • Determine the scaling properties of translocation time with the number of monomers (N).
  • Resolve the discrepancy between Brownian dynamics and Rouse dynamics predictions for polymer translocation.

Main Methods:

  • Numerical simulations using Rouse dynamics.
  • Studied phantom polymer chains in d=1 and d=2 spatial dimensions.

Related Experiment Videos

  • Analyzed self-avoiding polymer chains in d=2 spatial dimensions.

    • Main Results:

    • Translocation times scale anomalously with N for large polymers, mirroring diffusion time scaling.
    • A prefactor dependent on pore size modifies the scaling relationship.
    • Predicted non-diffusive fluctuations in monomer number at short times.
    • Derived the N-dependence of average pulling velocity under a chemical potential gradient.

    Conclusions:

    • Polymer translocation dynamics are more complex than predicted by simple Brownian models.
    • Rouse dynamics provide a more accurate framework for understanding large polymer translocation.
    • Anomalous scaling suggests unique physical mechanisms govern the translocation process.