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The lipoprotein and lipid pattern in xanthomatosis
Acta Medica Scandinavica
|September 1, 1975
Summary
Xanthomatosis is strongly linked to elevated plasma lipid and lipoprotein levels, particularly cholesterol. The study found that xanthoma size and occurrence increase with age and higher cholesterol, impacting tendons and fingers.
Area of Science:
- Biochemistry
- Genetics
- Dermatology
Background:
- Xanthomatosis is a condition characterized by the deposition of lipids in the skin and tendons.
- Understanding the relationship between xanthomatosis and plasma lipid profiles is crucial for patient management.
Purpose of the Study:
- To investigate the association between xanthomatosis and plasma lipid and lipoprotein concentrations.
- To identify common sites and age of onset for xanthomas.
Main Methods:
- A study of 336 individuals diagnosed with xanthomatosis.
- Analysis of plasma lipid and lipoprotein levels, including cholesterol, triglycerides, and LDL cholesterol.
- Assessment of xanthoma localization, size, and age of onset.
Main Results:
- Elevated cholesterol levels were observed in 5/6 of subjects with xanthomatosis.
- Xanthoma size and number of affected sites correlated with age and cholesterol levels.
- Common sites included finger extensors (more in males) and Achilles tendons (more in females).
Conclusions:
- Xanthomatosis is predominantly associated with hyperlipidemia, particularly elevated cholesterol.
- Lipoprotein patterns, such as Type IIA and IIB hyperlipoproteinemia, are frequently observed.
- Age and cholesterol levels significantly influence xanthoma presentation.