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Novel translocation (9;12)(q22;q24) in secondary chondrosarcoma arising from hereditary multiple exostosis
Francis Young-In Lee1, Mark Zawadsky, May Parisien
1Department of Orthopaedic Surgery, College of Physicians and Surgeons of Columbia University, 622 W. 168th St., PH 11, New York, NY, USA. fl127@columbia.edu
Cancer Genetics and Cytogenetics
|January 22, 2002
Abstract:
We report a new translocation in a patient with a history of hereditary multiple exostosis (HME) who developed a recurrent grade I chondrosarcoma involving the sacrum and retroperitoneum. Karyotypic analysis of the tumor revealed a sole chromosome abnormality t(9;12)(q22;q24.3). To our knowledge, this translocation has not been previously identified in either chondrosarcoma, HME, or related tumor types. Our novel translocation may be related to the sarcomatous degeneration of the pre-existing exostosis.