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Glial processes are glued to synapses via Ca(2+)-permeable glutamate receptors
1Dept of Anatomy, Hokkaido University School of Medicine, 060-8638, Sapporo, Japan. watamasa@med.hokudai.ac.jp
Trends in Neurosciences
|January 22, 2002
Abstract:
Bergmann glia in the cerebellum elaborately ensheathe Purkinje cell dendrites and synapses, and express high levels of Ca(2+)-permeable glutamate receptors (GluRs). Suppression of the Ca(2+) permeability by virus-mediated GluR2 transfer has revealed that GluR-mediated Ca(2+) signaling is essential to maintain both structural and functional connections between the glial cell and the glutamatergic synapses.