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Updated: Aug 17, 2026

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Organotypic Slice Cultures of Embryonic Ventral Midbrain: A System to Study Dopaminergic Neuronal Development in vitro
Published on: January 31, 2012
Hedgehog patterns midbrain ARChitecture
1Developmental Genetics Program and the Dept of Cell Biology, The Skirball Institute of Biomolecular Medicine, NYU Medical Center, 540 First Avenue, NY 10016, USA.
Trends in Neurosciences
|January 22, 2002
Abstract:
Recent work from Agarwala et al. has uncovered exquisite ventral patterning in the mesencephalon. Using electroporation in chicks, they show that ectopic expression of Sonic Hedgehog (Shh) in dorsal mesencephalon can recapitulate this patterning in its entirety. These results are discussed in the context of the purported role of Shh as a morphogen.

