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Metastatic meningioma to the lung with multiple pleural metastases
J M Kaminski1, B Movsas, E King
1Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Abstract:
Meningiomas with both malignant clinical behavior and cytology are rare. Meningiomas comprise approximately 15% of the primary brain tumors. The majority are benign; less than 1% metastasize, most commonly to the lung (61%) followed by liver, lymph node, and bone. Approximately 130 cases of extracranial metastatic meningiomas have been described. Only 13% had more than three metastases, with few cases reported with extensive pleural involvement. We report an interesting case of a malignant meningioma that invaded through the skull in the frontal sinus that later metastasized to the left lung with multiple pulmonary and pleural nodules.
Insights
Malignant meningiomas are rare brain tumors. This case highlights unusual skull invasion and extensive lung metastasis, emphasizing the need for vigilance in rare meningioma presentations.
Area of Science:
- Neuro-oncology
- Pathology
- Neurosurgery
Background:
- Meningiomas are the most common primary brain tumors, typically benign.
- Malignant meningiomas are rare, with less than 1% metastasizing extracranially.
- Extensive pleural involvement is infrequently reported in metastatic meningiomas.
Observation:
- A rare case of malignant meningioma with skull invasion into the frontal sinus is presented.
- The tumor exhibited aggressive behavior and extensive pleural metastasis.
- Multiple pulmonary and pleural nodules were observed in the left lung.
Findings:
- This case demonstrates an unusual pattern of extracranial invasion and widespread metastasis.
- The patient presented with a malignant meningioma invading the frontal sinus.
- Metastasis to the lung, including pleural nodules, was confirmed.
Implications:
- This case underscores the importance of considering malignant meningioma in aggressive presentations.
- Early detection and comprehensive management are crucial for patients with metastatic meningiomas.
- Further research into the metastatic potential and behavior of meningiomas is warranted.