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Histamine content and synthesis in central and pheripheral nerve structures during stress
Agents and Actions
|February 1, 1975
Summary
Electrical stress significantly alters histamine levels and activity in the guinea-pig nervous system. Histidine decarboxylase activity increases in the brain, while histamine content decreases in the brain and peripheral nerves.
Area of Science:
- Neuroscience
- Biochemistry
- Physiology
Background:
- Histamine plays a role in the central and peripheral nervous systems.
- Understanding histamine's response to stress is crucial for neurological research.
Purpose of the Study:
- To investigate the effects of electrical stress on histamine content and histidine decarboxylase activity in the guinea-pig nervous system.
- To explore the functional implications of these changes in the nervous system.
Main Methods:
- Assessed histamine content in brain regions (cortex, hypothalamus) and peripheral nervous structures.
- Measured histidine decarboxylase activity in the cortex and hypothalamus.
- Utilized electrically stressed and normal guinea-pig models.
Main Results:
- Electrical stress significantly increased histidine decarboxylase activity in the hypothalamus and cortex.
- A concomitant decrease in histamine content was observed in the hypothalamus.
- Histamine content decreased in the spinal cord, spinal ganglia, dorsal roots, and sensory nerves following electric shock.
Conclusions:
- Electrical stress induces significant neurochemical changes related to histamine metabolism.
- These findings suggest a complex role for histamine in the nervous system's response to stress.
- Further research is needed to fully elucidate histamine's function in neurological stress responses.