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Polycystic kidney disease as a new risk factor for coronary events
Rasmi Magadle1, Paltiel Weiner, Marinella Rabner
1Department of Medicine A, Hillel Yaffe Medical Center, Hadera, Israel. library@hillel-yaffe.health.gov.il
Insights
Polycystic kidney disease (PKD) is linked to coronary aneurysms (CA). In a family with PKD, a high prevalence of CA was found, with myocardial infarction (MI) as a complication.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Genetics
Background:
- The association between arterial aneurysms and polycystic kidney disease (PKD) is established.
- Myocardial infarction (MI) is a known complication of atherosclerotic coronary aneurysms (CA).
- Patients with PKD may be at increased risk for MI due to CA.
Purpose of the Study:
- To investigate the occurrence of CA and MI in relatives of a patient with PKD, CA, and MI.
- To assess the familial aggregation of these conditions.
Main Methods:
- Studied 12 first-order relatives of a patient with PKD, CA, and MI.
- Utilized electrocardiogram, thallium-image test, and echocardiography for MI assessment.
- Employed kidney ultrasonography for PKD detection and coronary angiography/ventriculography for CA and MI evaluation.
Main Results:
- PKD was diagnosed in seven (58%) family members.
- Coronary aneurysms (CA) were detected in five (42%) individuals.
- Myocardial infarction (MI) was identified in three (25%) family members.
Conclusions:
- A high prevalence of CA was observed in this family with PKD.
- MI occurred as a complication of CA in the affected individuals.
- These findings suggest a potential link between PKD and CA, increasing MI risk in affected families.
Background:
The association between coronary and/or other arterial aneurysms and polycystic kidney disease is well known. While myocardial infarction is a possible complication of atheroscletotic coronary aneurysms, it is reasonable to assume that CA in patients with PKD may make them prone for a similar complication.
Objective:
To evaluate the possible occurrence of CA and MI in first-order relatives of a patient with PKD, CA and MI.
Patients:
We studied 12 family members: 2 parents, 8 sisters and 2 brothers of a young woman who was incidentally diagnosed as having a MI, while her mother was known to have PKD. We used electrocardiogram, thallium-image test, and transthoracic echocardiography to determine MI, ultrasonography of the kidney to determine PKD, and coronary angiography and ventriculography to determine CA and MI, respectively.
Results:
PKD was detected in seven family members, while CA and MI were found in five and three of them, respectively.
Conclusions:
In a family with PKD we detected a high prevalence of CA, with MI as a complication of the latter.