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Vaccinations

Vaccinations

Pharmacovigilance

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...

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Vaccines

Vaccines

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Related Experiment Video

Updated: Jul 25, 2026

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Published on: May 2, 2011

The Vaccine Safety Datalink project.

F DeStefano¹,

¹National Immunization Program (MS-F34), Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. fxd1@cdc.gov

Pharmacoepidemiology and Drug Safety

|January 23, 2002

Summary

The Vaccine Safety Datalink (VSD) monitors vaccine safety using linked health data. This valuable resource provides crucial information on vaccine safety and coverage for millions of Americans.

Area of Science:

Public Health
Epidemiology
Immunization

Background:

The Vaccine Safety Datalink (VSD) is a CDC-led collaboration with health maintenance organizations (HMOs).
Established in 1990, its primary goal is to rigorously evaluate vaccine safety concerns.
It links computerized vaccination and medical outcome data for approximately 6 million individuals.

Purpose of the Study:

To rigorously evaluate concerns about vaccine safety.
To provide important information on vaccine safety issues.
To address other immunization questions, including vaccination coverage and cost-effectiveness.

Main Methods:

Prospective collection of linked computerized data on vaccination, medical outcomes, and covariates.
Utilizes data from multiple HMOs, initially four, expanding to ten for specific studies.

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Employs cohort study methodology to estimate incidence rates and risks.

Main Results:

The VSD has provided significant information on various vaccine safety issues.
Demonstrated value in assessing vaccine safety and coverage.
Expanded methodology successfully used to investigate intussusception following rotavirus vaccination.

Conclusions:

The VSD is a valuable resource for vaccine safety monitoring.
Its infrastructure supports research on vaccine safety, coverage, and cost-effectiveness.
The VSD methodology is adaptable for investigating specific vaccine safety concerns.