Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does Down's syndrome protect against multiple sclerosis?

Franz X Weilbach1, Klaus V Toyka

  • 1Department of Neurology, Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Julius Maximilians University, Würzburg, Germany. f.weilbach@mail.uni-wuerzburg.de

European Neurology
|January 23, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The history of the European Neurological Society (1986-2014)-10 years later.

European journal of neurology·2024
Same author

Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathy.

Molecular therapy : the journal of the American Society of Gene Therapy·2024
Same author

Temporary and highly variable recovery of neuromuscular dysfunction by electrical stimulation in the follow-up of acute critical illness neuromyopathy: a pilot study.

Neurological research and practice·2023
Same author

Temporary reversal of nerve and muscle dysfunction by serial electrical stimulation in critical illness neuromyopathy.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2022
Same author

Functional predictors of treatment induced diabetic neuropathy (TIND): a prospective pilot study using clinical and neurophysiological functional tests.

Diabetology & metabolic syndrome·2022
Same author

Inflammatory Mechanisms in the Pathophysiology of Diabetic Peripheral Neuropathy (DN)-New Aspects.

International journal of molecular sciences·2021
Same journal

Combined Olfactory Testing and Substantia Nigra Hyperechogenicity for Diagnostic Differentiation of Parkinson's Disease.

European neurology·2026
Same journal

The Role of Stroke Severity in the Association between Hypoperfusion Intensity Ratio and Futile Reperfusion after Endovascular Treatment.

European neurology·2026
Same journal

The Parkinsonism of Salvador Dalí.

European neurology·2026
Same journal

Disorders of Arousal and Sleep-Related Hypermotor Epilepsy in Adults: A Challenging but Necessary and Critical Distinctive Diagnosis.

European neurology·2026
Same journal

Sex-Specific Phenotypic Characteristics in Obstructive Sleep Apnea: A Comprehensive Analysis of Anthropometric, Hematological, and Metabolic Profiles Stratified by Disease Severity.

European neurology·2026
Same journal

Historical and Clinical Analysis of a Case of Progressive Muscular Atrophy (1853-1871).

European neurology·2026
See all related articles

Individuals with Down syndrome (DS) appear to have a lower risk of developing multiple sclerosis (MS), contrary to their higher risk for other autoimmune disorders. Genes on chromosome 21 may offer protection against MS.

Area of Science:

  • Immunogenetics
  • Neuroimmunology
  • Human Genetics

Background:

  • Down syndrome (DS) is associated with an increased incidence of certain autoimmune disorders.
  • However, only one case of co-occurrence between Down syndrome and multiple sclerosis (MS) has been documented.

Purpose of the Study:

  • To investigate the potential association between Down syndrome and multiple sclerosis.
  • To hypothesize a protective role for genes on chromosome 21 against MS development.

Main Methods:

  • Population and prevalence data were used to estimate the expected co-occurrence of DS and MS.
  • DS prevalence was estimated using live birth rates and life tables.

Main Results:

  • An expected 102 cases of MS were predicted among 116,939 individuals with DS in Western Europe.

Related Experiment Videos

  • Only one such case has been reported, suggesting a significant underrepresentation.

    • Conclusions:

    • A negative association between Down syndrome and multiple sclerosis is hypothesized.
    • Genes on chromosome 21, such as interferon receptors and S100b, may confer protection against MS.
    • Further research could elucidate the role of these genes in MS pathogenesis and autoimmune disease expression.