Related Experiment Video
Updated: Aug 15, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Effects of tibolone on thromboxane B(2) levels in postmenopausal women
Mukaddes Canbaz1, Pervin Vural, Cemil Akgül
1Department of Biochemistry and Clinical Biochemistry, Istanbul Medical Faculty, Istanbul, Turkey.
Abstract:
This study was carried out in 16 premenopausal (control) and 24 postmenopausal women (study group) to investigate the effect of menopause and tibolone treatment (2.5 mg/day for 6 months) on plasma thromboxane B(2) (TxB(2)), a well-known vasoconstrictor and stimulator of platelet aggregation. The TxB(2) levels were measured using [(125)I] RIA kit. Statistical significance was analyzed by Student's t test for paired and unpaired data, and Pearson's correlation analysis. Plasma TxB(2) concentrations of postmenopausal women were higher than those of premenopausal women. Tibolone treatment decreased plasma TxB(2) in postmenopausal women. There was no correlation between TxB(2) and blood pressure and heart rate. It was concluded that tibolone, decreasing the plasma concentrations of TxB(2), might have beneficial effects on prostaglandin metabolism and thus reduce the risk of cardiovascular disease.
Related Concept Videos
Drugs that Stabilize Microtubules
Therapeutic Index
Adrenergic Antagonists: ɑ and β-Receptor Blockers
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...

