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LIS1-no more no less
O Reiner1, A Cahana, T Escamez
1Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel.
Molecular Psychiatry
|January 23, 2002
Abstract:
LIS1 is one of the genes that has a principle role in brain development since hemizygote mutations in LIS1 result in a severe brain malformation known as lissencephaly ('smooth brain'). LIS1 is a WD repeat protein and is known to be involved in several protein complexes that are likely to play a functional role in brain development. We discuss here the brain developmental phenotype observed in mice heterozygote for an N-terminal truncated LIS1 protein in view of known LIS1 protein interactions.