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Related Experiment Videos

Intestinal entry of prions.

S Ghosh1

  • 1Gastrointestinal Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK. s.ghosh@ic.ac.uk

Zeitschrift Fur Gastroenterologie
|January 23, 2002
PubMed
Summary

Variant Creutzfeldt-Jakob disease (vCJD) may spread through prion protein uptake in the small intestine. The enteric nervous system

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Infectious Diseases

Background:

  • Variant Creutzfeldt-Jakob disease (vCJD) is linked to prion protein ingestion.
  • Prion protein uptake in the small intestine occurs via M-cell dependent or independent pathways.

Purpose of the Study:

  • To investigate the role of the small intestine in prion protein uptake and vCJD pathogenesis.
  • To identify potential receptors and pathways for prion protein entry and spread.

Main Methods:

  • Analysis of prion protein uptake mechanisms in the small intestine.
  • Examination of laminin receptor precursor expression.
  • Assessment of prion protein's role in the enteric nervous system.

Main Results:

  • Laminin receptor precursor, a prion protein receptor, is present on the small intestinal brush border in 40% of individuals.
  • The enteric nervous system's cellular prion protein may be a target for conversion and a route for CNS spread.

Conclusions:

  • The small intestine presents potential routes for prion protein entry.
  • The enteric nervous system is implicated in prion protein propagation to the central nervous system.

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