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Related Experiment Videos

Validity of quantitative tests measuring tremor.

A R Potvin, W W Tourtellotte, D N Snyder

    American Journal of Physical Medicine
    |October 1, 1975
    PubMed
    Summary
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    New accelerometer tests objectively measure tremor in clinical trials. These tests show consensual validity when compared to expert neurologist ratings for multiple sclerosis and parkinsonian patients.

    Area of Science:

    • Neurology
    • Biomedical Engineering
    • Clinical Trials

    Background:

    • Objective tremor measurement is crucial for clinical trial evaluation.
    • Existing clinical assessments for tremor can be subjective.
    • Accelerometer-based tests offer a potential for objective quantification.

    Purpose of the Study:

    • To develop and validate accelerometer-based tests for measuring tremor.
    • To assess the consensual validity of these tests against expert clinical ratings.
    • To evaluate the utility of these tests in clinical trials for neurological disorders.

    Main Methods:

    • Developed accelerometer tests for Resting, Sustention, and Static Intention Tremor.
    • Recruited 10 multiple sclerosis and 10 parkinsonian patients.

    Related Experiment Videos

  • Recorded patient performance via motion pictures for neurologist rating on a nine-point scale.
  • Compared quantitative accelerometer data with qualitative neurologist ratings.

    • Main Results:

    • Accelerometer-based tremor measurements demonstrated consensual validity.
    • Quantitative data correlated significantly with the senior neurologist's subjective ratings.
    • The developed tests provide objective and reliable tremor assessment.

    Conclusions:

    • Accelerometer-based tremor testing is a valid method for clinical evaluation.
    • This methodology supports objective assessment in clinical trials.
    • The approach can be applied to validate future clinical instruments for tremor assessment.