Atherogenesis markers in patients with chronic rejection of renal allografts

Patients with renal insufficiency are thought to be at the higher risk of atherosclerosis complications. In the present study we evaluated some atherogenesis risk factors in patients with biopsy proven chronic vascular rejection of transplanted kidney and compared them with matched groups of transplant recipients. Patients with chronic rejection had higher plasma levels of alfa-I-acid glycoprotein and fibrinogen as well as soluble P-selectin level. Surprisingly we found no differences in other adhesion molecules. In conclusion, patients with chronic renal graft rejection are at the higher risk of atherosclerosis development.