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Environment, genome and cancer.

L Wang1, S J Chen

  • 1Shanghai Second Medical University, Ruijin Hospital, Shanghai Institute of Hematology, 197 Rui Jin Road II, Shanghai 200025, R.R., China. mbsih@public2.sta.net.ch

Comptes Rendus De L'Academie Des Sciences. Serie III, Sciences De La Vie
|January 24, 2002
PubMed
Summary

Cancer arises from a combination of genetic and environmental factors, with genetics accounting for only 5%. Environmental influences and human genome variations significantly impact cancer development, suggesting future mortality reduction through environmental purification and high-risk population protection.

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Area of Science:

  • Oncology
  • Environmental Health
  • Genetics

Background:

  • Cancer is a significant global health threat with complex etiology.
  • While genetic factors contribute to cancer, environmental and nongenetic factors play a crucial role.
  • Genetic predisposition, influenced by human genome variations, accounts for approximately 5% of all cancers.

Purpose of the Study:

  • To explore the interplay between genetics, environment, and cancer development.
  • To highlight the significant role of external factors in neoplastic processes.
  • To identify strategies for reducing cancer mortality.

Main Methods:

  • Review of epidemiological data.
  • Analysis of laboratory research findings.
  • Integration of policy-making and clinical perspectives.

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Main Results:

  • Environmental factors are critical in cancer development, acting alongside genetic and acquired susceptibilities.
  • Human genome variations contribute to individual susceptibility to cancer.
  • A multifactorial approach combining research, policy, and clinical practice is essential.

Conclusions:

  • Environmental purification and targeted protection for high-risk populations can decrease cancer mortality.
  • Understanding the complex interaction between environment, genome, and cancer is key to effective prevention and control.
  • Future cancer control strategies must integrate diverse scientific and clinical insights.