Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vertebral wedge angle measured by morphometric X-ray absorptiometry.

L Ferrar1, G Jiang, R Eastell

  • 1Division of Clinical Sciences, University of Sheffield, UK.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|January 24, 2002
PubMed
Summary

Vertebral wedge angle measurements showed similar diagnostic value to height ratios for identifying vertebral deformities in women. Neither method demonstrated clear superiority for detecting moderate to severe deformities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of NAT10-Mediated ac4C Modification in Osteoblast Function and Bone Formation: Insights from Integrative Bioinformatics and Experimental Validation.

Physiological research·2026
Same author

Exploring the diagnostic value of dynamic contrast-enhanced and diffusion tensor imaging of intratumoural and peritumoural high-grade gliomas for distinguishing treatment response from tumour progression.

Clinical radiology·2026
Same author

Bevacizumab plus chemotherapy versus chemotherapy in untreated advanced non-squamous non-small-cell lung cancer patients with brain metastases (BAP BRAIN): an open-label, randomized, multicenter, phase III study.

ESMO open·2025
Same author

Correction to: Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors.

Cell death & disease·2025
Same author

Application of MRI imaging parameters in lumbar spine diseases: a review of the literature.

Clinical radiology·2024
Same author

Andrographolide restored production performances and serum biochemical indexes and attenuated organs damage in <i>Mycoplasma gallisepticum</i>-infected broilers.

British poultry science·2022

Area of Science:

  • Osteoporosis Research
  • Radiographic Assessment
  • Vertebral Morphometry

Background:

  • Vertebral wedge deformities are common in osteoporosis and can lead to vertebral fractures.
  • Traditional methods for assessing vertebral deformities include height ratios, but vertebral wedge angle may offer an alternative.
  • Previous studies suggest vertebral wedge angle may be less dependent on bone size than height ratios.

Purpose of the Study:

  • To compare mean vertebral wedge angle in young men and women using morphometric X-ray absorptiometry (MXA).
  • To evaluate the influence of age on vertebral wedge angle in women.
  • To compare the diagnostic performance of vertebral wedge angle versus anterior-posterior (ha/hp) height ratios in identifying vertebral deformities.

Main Methods:

Related Experiment Videos

  • Morphometric X-ray absorptiometry (MXA) was used to measure vertebral wedge angles and ha/hp height ratios.
  • Reference intervals were established for both measurements.
  • Agreement with semiquantitative assessment (SQ) of radiographs was evaluated using kappa statistics, sensitivity, and diagnostic values.

    • Main Results:

    • Mean vertebral wedge angle was similar in young men and women and did not significantly change with age in women.
    • Both vertebral wedge angle (mean + 2.0 SD) and ha/hp height ratio (mean - 3.0 SD) showed good agreement with semiquantitative assessment (kappa ≈ 0.75).
    • Sensitivity was marginally better for wedge angle for all deformity grades, but performance was similar for moderate to severe deformities.

    Conclusions:

    • Vertebral wedge angle and ha/hp height ratios have broadly similar diagnostic values for identifying vertebral deformities.
    • The study did not find strong evidence to prefer the vertebral wedge angle method over height ratios.
    • Further research may be needed to clarify the optimal method for detecting vertebral deformities in clinical practice.