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Updated: Jul 22, 2026

Analyzing Large Protein Complexes by Structural Mass Spectrometry
Published on: June 20, 2010
Computational aspects of protein identification by mass spectrometry
1Protein Informatics Group, Swiss Institute of Bioinformatics, CMU, Geneva. robin.gras@isb-sib.ch
Abstract:
Recent developments in proteomics and genomics provide huge quantities of data to analyze. Automatic interpretation of mass spectrometry data has become essential for high-throughput processes aiming to study complete proteomes. There exist two main sources of mass spectrometric data: peptide mass fingerprint and fragmentation spectra, both of which require specific bioinformatic algorithms. We present a survey of these algorithms and discuss the efficiency of the different approaches and the possible improvements that may lead to a complete automatic high-throughput identification process.
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